Curcumin, commonly called diferuloyl methane, is a hydrophobic polyphenol derived from the rhizome (turmeric) of the herb Curcuma longa which is a member of the ginger family (Zingiberaceae). Turmeric has been used traditionally for many ailments because of its wide spectrum of pharmacological activities. Curcumin is believed to be the most bioactive and soothing portion of the herb turmeric. Curcumin has antioxidant, anti-inflammatory, antiviral and antifungal actions. Studies have shown that curcumin is not toxic to humans. Turmeric (95 % curcumin) is effective in reducing post-surgical inflammation. It helps to prevent atherosclerosis by reducing the formation of bloods clumps. Nevertheless curcumin has extensive health benefits, pharmacokinetic studies in animals have demonstrated that 40-85 percent of an oral dose of curcumin passes through the gastrointestinal tract unchanged, with most of the absorbed flavonoid being metabolized in the intestinal mucosa and liver. CURCUBEST is a proprietary product from Vidya Herbs, with enhanced bioavailability. CURCUBEST is an organic turmeric extract with over 95 % curcuminoids and bioenhancers. At Vidya Herbs, we have evaluated the pharmacokinetics of CURCUBEST in preclinical models. Increased absorption of curcumin in the formulation prompted us to test the bioavailability in healthy human subjects. The increased bioavailability could be attributed to the non-curcuminoid components such as turmerones. The presence of α- and aromatic turmerones significantly increases the amount of curcumin transported into the cells. α-turmerone inhibits the activity of P-gp, a drug efflux pump. Pgp have been proven to have a very important role in inhibiting efficient drug entry into the systemic circulation. P-gp pumps drug molecules back out of cells with the help of changing ATP to ADP. This can lead to drug resistance. Turmerones in CURCUBEST acts as inhibitors that might block the action of P-gp by taking away its ATP or by competing with the drug for the pump, so less curcumin is pumped out. CURCUBEST is proven to be safe upon oral consumption as evident from our toxicity studies in preclinical models. Further, during the human clinical studies, no adverse events were reported. CURCUBEST is available as per stringent quality control.
Pomegranate is a major resource for the modern medicine. It is valued in Ayurveda as a powerful gift of nature against a long list of human ailments. Pomegranate is a fruit-bearing deciduous shrub or small tree growing between 5 and 8 m (16–26 ft) tall. Distribution: The pomegranate is considered to have originated in the region from Iran to northern India, and has been cultivated since ancient times throughout the Mediterranean region. Phytoconstituents: The peel, white pulp membrane, arils and seeds of the pomegranate all contain many chemical compounds of high biological value. About 50 % of the total weight of the pomegranate corresponds to the peel and white pulp membranes, which are a major source of bio-active compounds such as polyphenols, flavonoids, ellagitannins, proanthocyanidins and minerals, mainly potassium, nitrogen, calcium, phosphorus, magnesium and sodium. Pomegranate arils are composed of 85 % water, 10 % sugar (mainly fructose and glucose), 1.5 % organic acids (principally ascorbic, citric and malic acids) and bioactive compounds such as polyphenols and flavonoids (mainly anthocyanins). Pomegranate arils are also a major source of lipids, since fatty acids comprise between 12 % and 20 % of the total dry weight of the seeds. The fatty acid profile is characterised by a high content in unsaturated fatty acids, including linolenic, linoleic, punicic, oleic, stearic and palmitic acids. Health benefits: According to Ayurveda, sweet pomegranate is Tridohaghnam. It alleviates thirst, burning sensation, and fevers. It is known for aphrodisiac properties; useful in the treatment of diseases of the heart, throat and mouth. It improves intellect and strength. Pomegranate which is acidic and sour, improves appetite, and taste. The rind of the fruit and the bark of the pomegranate tree are used as a traditional remedy against diarrhea, dysentery, and intestinal parasites. Pomegranate has been used as a contraceptive and abortifacient by means of consuming the seeds, or rind, as well as by using the rind as a vaginal suppository.